纤维化(fibrosis)是一种病理改变,主要表现为器官组织内纤维结缔组织增多,实质细胞减少,持续进展可致器官结构破坏和功能减退,乃至衰竭,严重威胁人类健康和生命。纤维化可发生于多种器官,常见的包括肺脏、肝脏、肾脏、骨髓等。纤维化通常由各种刺激导致的慢性炎症性反应引起,包括:持续性感染,自身免疫反应,过敏性反应,化学刺激,射线和组织损伤等。
TargetMol 抗纤维化化合物库收集了1800 种抗纤维化分子和潜在的抗纤维化分子,包括相关靶点如TGFβ、TNFα、MMP 的抑制剂、抗氧化剂及抗炎分子等,是研究纤维化机制和开发抗纤维化药物的良好工具。
Empty | 99697-24-2 | 99464-64-9 | 99353-00-1 | 99-32-1 | 99-24-1 | 989-51-5 | 978-62-1 | 97-53-0 | 973-67-1 | 970-74-1 | Empty |
24-Norursodeoxycholic acid | Ampiroxicam | Methyl rosmarinate | Chelidonic acid | Methyl gallate | (-)-Epigallocatechin Gallate | IMD-0354 | Eugenol | 5,6,7-TRIMETHOXYFLAVONE | (-)-Epigallocatechin | ||
Empty | 96990-18-0 | 96574-01-5 | 96087-21-7 | 959841-49-7 | 95975-55-6 | 959551-10-1 | 958941-60-1 | 958852-01-2 | 957054-33-0 | 957054-30-7 | Empty |
Momordin Ic | Salvianolic acid A | Stylopine hydrochloride | (E)-Akt inhibitor-IV | Guggulsterone | NIH-12848 | CFTR corrector 12 | GSK1059615 | Pictilisib dimethanesulfonate | Pictilisib | ||
Empty | 956958-53-5 | 955977-50-1 | 95311-94-7 | 952021-60-2 | 950736-05-7 | 94805-82-0 | 946518-60-1 | 946128-88-7 | 946002-48-8 | 945755-56-6 | Empty |
Pilaralisib analogue | PI-3065 | Lucideric acid A | PF 477736 | B-Raf IN 1 | Glycycoumarin | LY2409881 trihydrochloride | Ro 5126766 | SAG 21k | XL019 | ||
Empty | 945619-74-9 | 945614-12-0 | 945595-80-2 | 945189-68-4 | 94492-24-7 | 944396-07-0 | 943820-93-7 | 943764-99-6 | 943319-70-8 | 942918-07-2 | Empty |
OPHIOPOGONIN D | Pexmetinib | AMG 900 | SJ000063181 | 2'-acetylacteoside | Buparlisib | Wnt/β-catenin agonist 2 | Acebilustat | Ponatinib | GSK-1070916 | ||
Empty | 942655-44-9 | 942507-42-8 | 942425-68-5 | 942183-80-4 | 941685-37-6 | 941678-49-5 | 94055-76-2 | 940310-85-0 | 938440-64-3 | 937807-66-4 | Empty |
JK-P3 | AZ304 | PHA-767491 hydrochloride | SCH772984 | Ruxolitinib (S enantiomer) | Ruxolitinib | Suplatast (Tosilate) | NVP-BHG712 | KU-0063794 | Neurodazine | ||
Empty | 937272-79-2 | 937174-76-0 | 936890-98-1 | 936727-05-8 | 936091-26-8 | 935273-79-3 | 934826-68-3 | 934660-93-2 | 934541-31-8 | 934526-89-3 | Empty |
Pacritinib | GSK-690693 | OSI-027 | Lumacaftor | Fedratinib | MK-4101 | Visomitin | Cobimetinib | TAK-901 | Pilaralisib | ||
Empty | 934493-76-2 | 934389-88-5 | 934353-76-1 | 93-35-6 | 931706-15-9 | 931695-79-3 | 93-07-2 | 929007-72-7 | 928037-13-2 | 927880-90-8 | Empty |
Voxtalisib | LY-294002 hydrochloride | ENMD-2076 | Umbelliferone | PPQ-102 | ML-191 | Veratric acid | DB07268 | Golvatinib | RAF265 | ||
Empty | 925705-73-3 | 925701-49-1 | 923564-51-6 | 923032-37-5 | 919936-70-2 | 918505-84-7 | 918505-61-0 | 918504-65-1 | 917111-44-5 | 916232-21-8 | Empty |
TG 100713 | KU60019 | Navitoclax | Refametinib | GS87 | PLX-4720 | BRAF inhibitor | Vemurafenib | Lexibulin | GS143 |