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血脑屏障通透化合物库 
CNS-Penetrant Compound Library
产品编号: L5900
血脑屏障是由毛细血管内皮细胞及其之间的紧密链接组成，保护大脑免受外界异质物质的破坏，限制物质分子扩散进入中枢神经系统，由于血脑屏障的阻碍作用，脑肿瘤等疾病的化疗功效也受到很大影响。因此治疗大多数脑疾病的主要挑战是将治疗药物穿过血脑屏障递送到大脑的特定区域，在针对 CNS 靶标筛选库的设计中选择能够穿透血脑屏障的分子，对于整个 CNS 药物发现过程起着至关重要的作用。 我们精心挑选了 660 个血脑屏障通透性化合物，有明确作用靶点、生物活性验证有效，用于 CNS-Penetrant 相关的研究及中枢神经系统疾病药物的筛选，可用于高通量、高内涵筛选。
陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。
产品编号: L5900
规格
1 mg
30 μL x 10 mM (in DMSO)
50 μL x 10 mM (in DMSO)
100 μL x 10 mM (in DMSO)
250 μL x 10 mM (in DMSO)
特别折扣
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技术资料
陶术生物化合物库目录(60.2 MB) 
库化合物信息
Excel 
SDF 产品描述
产品描述:
- 660 个CNS-Penetrant生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
- 靶点包括激酶、GPCR和离子通道等；
- 是脑肿瘤、精神障碍和神经退行性疾病等脑疾病药物筛选的有效工具；
- 结构多样，药效显著，可渗透血脑屏障和细胞；
- 详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
- NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。
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