药物功能重定位化合物库

Drug Repurposing Compound Library

产品编号: L9200

传统的药物开发涉及从头确认和验证新分子实体，这是一个耗时且成本高昂的过程，随着对药物安全性及有效性的要求不断提高，开发新药的成本还将持续上涨。由于时间和成本大幅降低，近年来药物功能重定位受到越来越多关注，高内涵筛选、新的生物标志物发现和生物信息学的快速发展为基于靶点或细胞的药物重定位创造了机会。 TargetMol 药物功能重定位化合物库收集了4960 种已上市和进入临床期的药物，这些化合物经过大量的临床前研究实验，具有活性高、毒性低和机制明确的特点，适用于药物筛选的同时，也是细胞诱导分化的有力工具。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品编号: L9200

规格

1 mg

30 μL x 10 mM (in DMSO)

50 μL x 10 mM (in DMSO)

100 μL x 10 mM (in DMSO)

250 μL x 10 mM (in DMSO)

特别折扣
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技术资料

陶术生物化合物库目录(60.2 MB)

化合物库操作手册(635 KB)

库化合物信息

Excel

SDF

产品描述

产品描述:

4960种全球上市药物和临床药物的独特集合，可用于高通量筛选和高内涵筛选，是老药新用、新的药物靶点筛选和细胞诱导的有效工具。
是整个行业规模领先的药物功能重定位化合物库；
所有上市化合物得到FDA、EMA、NMPA等权威部门审批或收录在USP、EP、BP、JP、CP等药典文献中；
涵盖多个研究领域：肿瘤、心血管药物、抗炎/免疫、神经系统药物、呼吸系统药物等；
靶点多样，包括5-HT Receptor、Sodium Channel、p38 MAPK、PI3K、MEK等；
详细的说明书，化合物结构、靶点信息、适应症信息、活性描述等；
结构多样，药效显著，可渗透细胞；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

我们的化合物库可以灵活定制！了解更多

化合物库咨询

化合物库组成

Autophagy

Antibacterial

Apoptosis

Antibiotic

Others

Endogenous Metabolite

5-HT Receptor

Adrenergic Receptor

AChR

Dopamine Receptor

Histamine Receptor

COX

HIV Protease

Parasite

DNA/RNA Synthesis

Sodium Channel

Antifungal

Potassium Channel

Calcium Channel

VEGFR

EGFR

Topoisomerase

PDE

PI3K

Glucocorticoid Receptor

Reactive Oxygen Species

SARS-CoV

Cytochromes P450

Dehydrogenase

CDK

Estrogen/progestogen Receptor

HCV Protease

Influenza Virus

FLT

Ferroptosis

PPAR

NF-κB

GABA Receptor

PDGFR

Microtubule Associated

JAK

c-Kit

HDAC

FGFR

RAAS

c-Met/HGFR

Estrogen Receptor/ERR

mTOR

Prostaglandin Receptor

HBV

Mitophagy

Nucleoside Antimetabolite/Analog

Androgen Receptor

Src

Adenosine Receptor

Reverse Transcriptase

Tyrosine Kinases

iGluR

Serotonin Transporter

NMDAR

Bcr-Abl

Cholinesterase (ChE)

GPR

TRP/TRPV Channel

HSV

Norepinephrine

Proteasome

HER

Virus Protease

MAO

Raf

GluR

Antiviral

ATPase

PARP

ribosome

TNF

Phosphatase

Progesterone Receptor

Opioid Receptor

Epigenetic Reader Domain

Akt

HSP

p38 MAPK

Antioxidant

ROS

Beta Amyloid

Carbonic Anhydrase

Transferase

PKC

IL Receptor

Aurora Kinase

P-gp

MMP

ALK

HIF/HIF Prolyl-Hydroxylase

Proton pump

MEK

Histone Methyltransferase

Antifection

DPP-4

TLR

c-RET

Monoamine Oxidase

Thyroid hormone receptor(THR)

DNA Alkylator/Crosslinker

Drug Metabolite

Mitochondrial Metabolism

Endothelin Receptor

ERK

Interleukin

Thrombin

Trk receptor

Bcl-2 Family

AMPK

Phospholipase

GSK-3

P2X Receptor

CXCR

Retinoid Receptor

c-Fms

HMG-CoA Reductase

Integrin

GNRH Receptor

MRP

Caspase

ROCK

CCR

Lipoxygenase

SGLT

STAT

TAM Receptor

S1P Receptor

Factor Xa

PKA

Gamma-secretase

Vasopressin Receptor

Chk

Neurokinin receptor

FAK

NO Synthase

DNA-PK

NADPH

E1/E2/E3 Enzyme

Guanylate cyclase

DNA Alkylation

HIF

Cannabinoid Receptor

Syk

CFTR

p53

LPL Receptor

Reductase

Wnt/beta-catenin

Serine Protease

Antifolate

TGF-beta/Smad

Nrf2

DHFR

Amino Acids and Derivatives

P2Y Receptor

Glutathione Peroxidase

FXR

DNA gyrase

Hedgehog/Smoothened

IGF-1R

RSV

Sigma receptor

ROS Kinase

NOS

Histone Demethylase

IAP

CSF-1R

BTK

ATM/ATR

Hydroxylase

PLK

Tyrosinase

ADC Cytotoxin

Mdm2

Chloride channel

CETP

Leukotriene Receptor

ABC Transporter

OX Receptor

CaMK

Indoleamine 2,3-Dioxygenase (IDO)

DNA Methyltransferase

S6 Kinase

BACE

JNK

Cholecystokinin Receptor

Cysteine Protease

Glucosidase

Smo

Xanthine Oxidase

Ligand for E3 Ligase

Kinesin

Glucokinase

Aryl Hydrocarbon Receptor

RIP kinase

Glucagon Receptor

DNA

Beta-Secretase

Acyltransferase

Aminopeptidase

Sirtuin

Casein Kinase

Aromatase

ROR

Pim

Liver X Receptor

Monoamine Transporter

Molecular Glues

Isocitrate Dehydrogenase (IDH)

Fatty Acid Synthase

PAK

Bradykinin Receptor

PGE Synthase

IκB/IKK

GHSR

CGRP Receptor

Gap Junction Protein

NOD

IRAK

AhR

LTR

IFNAR

Tie-2

IDO

MT Receptor

GlyT

FAAH

MAPK

GPCR19

Ephrin Receptor

CRFR

Melanocortin Receptor

Complement System

NADPH-oxidase

Imidazoline Receptor

PROTACs

CRM1

DprE1

YAP

Cell wall

Melatonin Receptor

CaSR

Serine/threonin kinase

Annexin A

UGT

Neuropeptide Y Receptor

Somatostatin

Wee1

Lipid

OAT

STING

Decarboxylase

Neprilysin

GST

Acetyl-CoA Carboxylase

Kras

LPA Receptor

PDK

Oxytocin Receptor

Anti-infection

Ras

NOD-like Receptor (NLR)

PD-1/PD-L1

MicroRNA

Monocarboxylate transporter

Arginase

Rho

NAMPT

PYK2

Glutaminase

Myosin

LDL

Na-K-Cl cotransporter

Hexokinase

Epoxide Hydrolase

KSP

DUB

Telomerase

Free radical scavengers

transporter

Adenosine Deaminase

Protease-activated Receptor

Vitamin

Advanced Glycation End Products

Taste receptor

GSNOR

NEDD8

Ligands for Target Protein for PROTAC

Lipase

PERK

TOPK

VDA

c-Myc

Galectin

Kisspeptin

IRE1

FLAP

Integrase

HCN Channel

Stearoyl-CoA Desaturase (SCD)

Thrombopoietin Receptor

ATP Citrate Lyase

BCRP

Glutathione reductase

Porcupine

CD73

GluCls

PAI-1

Pyroptosis

Aquaporin

Discoidin Domain Receptor (DDR)

p97

MLK

Apelin receptor

Adenylyl Cyclase

NPC1L1

Hydrogenase

RAR/RXR

MALT

Dynamin

Arrestin

Na+/Ca2+ Exchanger

DYRK

gp120/CD4

GTPase

N-Acetylglucosaminyltransferase

AAK1

VDAC

Hck

Neurotensin Receptor

LIM Kinase

Stemness kinase

Immunology/Inflammation related

SIK

Adiponectin Receptor

PAFR

MTH1

Fas/FasL

GRK

Phosphorylase

Anion Exchanger

PROTAC Linker

Thioredoxin

ACK1

Angiotensin-converting Enzyme (ACE)

PAD

cAMP

Mucin

Huntingtin

MNK

Survivin

Histone Acetyltransferase

ASK

MELK

Methionine Adenosyltransferase (MAT)

Hippo pathway

PI4K

KLF

CRISPR/Cas9

RXFP receptor

SGK

Platelet aggregation

BMI-1

PKM

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