研究表明生物体受刺激或扰动后(如低氧、营养物质、药物等)代谢产物会发生变化,基于肿瘤细胞内、外相关特征性小分子代谢标记物的异常变化来诊断恶性肿瘤、进行药物筛选、评价药物毒性等的方法也逐渐成为研究热点。癌细胞具有一种独特的、有别于正常细胞的代谢表型,监测癌细胞代谢过程中小分子代谢物的波动情况,将有利于预测肿瘤的进展、了解体内物质代谢途径、探索癌症发病机制及药物作用机制等。目前的研究主要集中于与癌细胞能量代谢相关的化合物研究,如核苷类、氨基酸类、脂类、糖类等。例如,已发现多种与肿瘤相关的脂类标记物, 胆碱、磷酸胆碱、磷酸卵磷脂、胆固醇等脂类变化谱是细胞膜破坏的标志;丙酮酸、乳酸、异丁酸等是与肿瘤细胞糖代谢相关的生物标记物, 探索通过靶向脂代谢、糖代谢途径治疗恶性肿瘤的策略正备受关注。 TargetMol 人内源代谢化合物库由1000种与内源代谢相关的生物活性化合物组成,可用于研究内源性代谢疾病和新药筛选。
Empty | 99-96-7 | 99-94-5 | 997-55-7 | 99-50-3 | 99-20-7 | 99-14-9 | 99-10-5 | 99-06-9 | 98-98-6 | 98-92-0 | Empty |
4-Hydroxybenzoic acid | p-Toluic Acid | N-Acetyl-L-aspartic acid | Protocatechuic acid | D-(+)-Trehalose | Tricarballylic acid | 3,5-Dihydroxybenzoic acid | 3-Hydroxybenzoic acid | PCL 016 | Nicotinamide | ||
Empty | 98-89-5 | 98-86-2 | 98-79-3 | 987-78-0 | 979-92-0 | 97-69-8 | 97-67-6 | 97-59-6 | 97540-22-2 | 96-81-1 | Empty |
Cyclohexanecarboxylic Acid | Acetophenone | L-Pyroglutamic acid | Citicoline | SAH | Ac-Ala-OH | (S)-Malic acid | Allantoin | S-Adenosyl-L-methionine disulfate tosylate | Acetylvaline | ||
Empty | 96-76-4 | 96-26-4 | 96-17-3 | 961-07-9 | 958-09-8 | 951-78-0 | 951-77-9 | 95-01-2 | 94-75-7 | 944-73-0 | Empty |
2,4-Di-tert-butylphenol | 1,3-Dihydroxyacetone | 2-Methylbutyraldehyde | 2'-Deoxyguanosine | 2'-Deoxyadenosine | 2'-Deoxyuridine | 2'-Deoxycytidine | 2,4-Dihydroxybenzaldehyde | 2,4-D | 1,3-Dimethyluric acid | ||
Empty | 94421-68-8 | 94-26-8 | 94249-01-1 | 94-13-3 | 938-55-6 | 93-60-7 | 93-51-6 | 93380-12-2 | 93-10-7 | 93-08-3 | Empty |
Anandamide | Butylparaben | Acetyl phosphate(lithium potassium) | Propylparaben | 6-(Dimethylamino)purine | Methyl nicotinate | Creosol | Epirosmanol | Quinoline-2-carboxylic acid | 2-Acetonaphthone | ||
Empty | 928-96-1 | 923-37-5 | 922-32-7 | 921-62-0 | 921-01-7 | 920-49-0 | 91510-62-2 | 911-40-0 | 90-80-2 | 90-64-2 | Empty |
cis-3-Hexen-1-ol | N-Carbamoyl-DL-aspartic acid | Phosphocreatine disodium | 6-Phosphogluconic acid | D-Cysteine | D-(-)-Lactic acid sodium | D-Galacturonic acid hydrate | 7-keto-deoxycholic acid | D-(+)-Glucono-1,5-lactone | Mandelic acid | ||
Empty | 90-50-6 | 90-27-7 | 9005-79-2 | 89-86-1 | 890-38-0 | 89-00-9 | 88-99-3 | 88847-89-6 | 88546-55-8 | 884-33-3 | Empty |
3,4,5-Trimethoxycinnamic acid | 2-Phenylbutanoic acid | Glycogen, Mussel | 2,4-Dihydroxybenzoic acid | 2'-Deoxyinosine | Quinolinic acid | Phthalic acid | 8-Hydroxy-2'-deoxyguanosine | Omeprazole metabolite Omeprazole sulfone | 2-Benzylsuccinic acid | ||
Empty | 88-14-2 | 88-09-5 | 87-99-0 | 879-37-8 | 87-89-8 | 87-69-4 | 87-66-1 | 87-51-4 | 874-24-8 | 871-70-5 | Empty |
2-Furoic acid | 2-Ethylbutyric Acid | Xylitol | Indole-3-acetamide | i-Inositol | L-Tartaric acid | Pyrogallol | 3-Indoleacetic acid | 3-Hydroxypicolinic acid | Octadecanedioic acid | ||
Empty | 87096-84-2 | 86933-74-6 | 869-19-2 | 86-87-3 | 863239-61-6 | 86227-47-6 | 85-87-0 | 85-61-0 | 853645-22-4 | 85-32-5 | Empty |
Neuromedin B | Neurokinin A | Glycyl-L-leucine | 1-Naphthaleneacetic acid | Tauro-Obeticholic acid | Eicosapentaenoic acid ethyl ester | Pyridoxylamine | Coenzyme A | Pyridoxal 5'-phosphate hydrate | 5'-Guanylic acid |