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神经信号分子库 
Neuronal Signaling Compound Library
产品编号: L2600
神经元之间和神经元内部的通信对于神经系统的所有功能至关重要，无论是从发育到衰老，还是从健康到疾病。在过去十年中，我们对神经系统内分子、细胞和系统信号通路的认识取得了巨大进步，在信号通路研究方面取得了重大突破，这些神经信号通路是神经发生、成瘾、自闭症以及情绪障碍的病理生理学和治疗基础。例如：G 蛋白偶联受体（GPCR），包括5-HT 受体、组胺受体、阿片受体等，是研究较多的神经元信号传导途径，GPCR 功能障碍会引起多种神经疾病；Notch 信号途径调节神经干细胞增殖、存活、自我更新和分化，Notch 信号传导异常参与中风、阿尔茨海默病和CNS 肿瘤等疾病中发生的病理过程。因此靶向神经元信号传导，可以用来治疗多种不同CNS 疾病。
TargetMol 神经信号分子库包含2771 种神经信号相关的小分子化合物，主要用于神经系统类疾病的药物研发，可用于高通量、高内涵筛选。
陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。
产品编号: L2600
规格
1 mg
30 μL x 10 mM (in DMSO)
50 μL x 10 mM (in DMSO)
100 μL x 10 mM (in DMSO)
250 μL x 10 mM (in DMSO)
特别折扣
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技术资料
陶术生物化合物库目录(60.2 MB) 
库化合物信息
Excel 
SDF 产品描述
产品描述:
- 2771种CNS相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
- 靶点包括5-HT receptor、AChR、Histamine receptor、dopamine receptor、Opiod receptor等；
- 结构多样，药效显著，可渗透细胞；
- 详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
- NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。
化合物库定制
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化合物库组成
5-HT Receptor
AChR
COX
Adrenergic Receptor
Dopamine Receptor
Histamine Receptor
GABA Receptor
Calcium Channel
GluR
TRP/TRPV Channel
Cholinesterase (ChE)
Apoptosis
Adenosine Receptor
Autophagy
Endogenous Metabolite
NMDAR
iGluR
Opioid Receptor
MAO
Beta Amyloid
Antibacterial
NF-κB
P-gp
Gamma-secretase
Monoamine Oxidase
P2X Receptor
Cannabinoid Receptor
Potassium Channel
Parasite
Norepinephrine
Serotonin Transporter
FAAH
CaMK
Sodium Channel
Cytochromes P450
Neurokinin receptor
Reactive Oxygen Species
Neuropeptide Y Receptor
TNF
BACE
NO Synthase
PDE
Lipoxygenase
Sigma receptor
GPR
Antibiotic
P2Y Receptor
OX Receptor
Antioxidant
PPAR
Influenza Virus
NOS
IL Receptor
HIV Protease
Beta-Secretase
Prostaglandin Receptor
Antifungal
Ferroptosis
ERK
ROS
Melatonin Receptor
Phospholipase
Imidazoline Receptor
HER
Virus Protease
Caspase
Akt
Adenylyl Cyclase
p38 MAPK
Drug Metabolite
MT Receptor
GlyT
EGFR
PGE Synthase
Chloride channel
Mitophagy
Interleukin
DNA/RNA Synthesis
Bcl-2 Family
STAT
Melanocortin Receptor
Carbonic Anhydrase
Transferase
HCV Protease
Estrogen/progestogen Receptor
Dehydrogenase
Phosphatase
PKA
Wnt/beta-catenin
AAK1
PKC
Glucocorticoid Receptor
SARS-CoV
AMPK
GSK-3
MRP
Monoamine Transporter
HSV
MMP
IκB/IKK
CGRP Receptor
Tyrosinase
ATPase
Src
PI3K
Histone Demethylase
Glutathione Peroxidase
Cholecystokinin Receptor
Serine/threonin kinase
Immunology/Inflammation related
Antifection
TGF-beta/Smad
TLR
Anti-infection
Melanin-concentrating Hormone Receptor (MCHR)
Histone Methyltransferase
Na+/Ca2+ Exchanger
Reductase
RAAS
JNK
PARP
Neurotensin Receptor
VEGFR
Topoisomerase
PAFR
CDK
ABC Transporter
Mitochondrial Metabolism
CCR
Epoxide Hydrolase
cAMP
mTOR
Acyltransferase
transporter
GST
HDAC
MEK
Microtubule Associated
HIF/HIF Prolyl-Hydroxylase
Advanced Glycation End Products
Transaminase
Amino Acids and Derivatives
Others
Arrestin
IFNAR
DYRK
NADPH
Lipase
Progesterone Receptor
Estrogen Receptor/ERR
HBV
Leukotriene Receptor
ROCK
IAP
UGT
Bcr-Abl
Glucosidase
JAK
Aurora Kinase
Epigenetic Reader Domain
IGF-1R
DNA
Androgen Receptor
BCRP
MAPK
Nrf2
GluCls
RSV
ATM/ATR
Hydroxylase
Platelet aggregation
NOD
DNA Methyltransferase
FAK
p53
Proteasome
MicroRNA
Monocarboxylate transporter
ROR
c-Met/HGFR
LPL Receptor
Glutaminyl Cyclase
LTR
Neuropeptide W
gp120/CD4
GTPase
N-Acetylglucosaminyltransferase
Antifolate
Cell Cycle Arrest
Nucleoside Antimetabolite/Analog
Cysteine Protease
FXR
LIM Kinase
Aryl Hydrocarbon Receptor
Myosin
Annexin A
FLAP
Adiponectin Receptor
LDL
Raf
Glucagon Receptor
Anion Exchanger
HCN Channel
MAGL
Fatty Acid Synthase
PAK
Bombesin Receptor
Stearoyl-CoA Desaturase (SCD)
ACK1
Angiotensin-converting Enzyme (ACE)
Somatostatin
Indoleamine 2,3-Dioxygenase (IDO)
Antiviral
HSP
STING
Free radical scavengers
GPCR19
Aminopeptidase
Casein Kinase
Reverse Transcriptase
Retinoid Receptor
CRISPR/Cas9
Adenosine Deaminase
FGFR
Gap Junction Protein
NMU2R
FLT
Syk
NADPH-oxidase
HMG-CoA Reductase
Thrombin
Protease-activated Receptor
Lysosomal Autophagy
NOD-like Receptor (NLR)
ROS Kinase
AhR
CFTR
S1P Receptor
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