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神经信号分子库 
Neuronal Signaling Compound Library
产品编号: L2600
神经元之间和神经元内部的通信对于神经系统的所有功能至关重要，无论是从发育到衰老，还是从健康到疾病。在过去十年中，我们对神经系统内分子、细胞和系统信号通路的认识取得了巨大进步，在信号通路研究方面取得了重大突破，这些神经信号通路是神经发生、成瘾、自闭症以及情绪障碍的病理生理学和治疗基础。例如：G 蛋白偶联受体（GPCR），包括5-HT 受体、组胺受体、阿片受体等，是研究较多的神经元信号传导途径，GPCR 功能障碍会引起多种神经疾病；Notch 信号途径调节神经干细胞增殖、存活、自我更新和分化，Notch 信号传导异常参与中风、阿尔茨海默病和CNS 肿瘤等疾病中发生的病理过程。因此靶向神经元信号传导，可以用来治疗多种不同CNS 疾病。
TargetMol 神经信号分子库包含2771 种神经信号相关的小分子化合物，主要用于神经系统类疾病的药物研发，可用于高通量、高内涵筛选。
陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。
产品编号: L2600
规格
1 mg
30 μL x 10 mM (in DMSO)
50 μL x 10 mM (in DMSO)
100 μL x 10 mM (in DMSO)
250 μL x 10 mM (in DMSO)
特别折扣
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技术资料
陶术生物化合物库目录(60.2 MB) 
库化合物信息
Excel 
SDF 产品描述
产品描述:
- 2771种CNS相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
- 靶点包括5-HT receptor、AChR、Histamine receptor、dopamine receptor、Opiod receptor等；
- 结构多样，药效显著，可渗透细胞；
- 详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
- NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。
化合物库定制
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化合物库组成
5-HT Receptor
AChR
COX
Adrenergic Receptor
Dopamine Receptor
Histamine Receptor
Calcium Channel
GABA Receptor
GluR
TRP/TRPV Channel
Cholinesterase (ChE)
Autophagy
Apoptosis
Adenosine Receptor
Endogenous Metabolite
NMDAR
iGluR
Opioid Receptor
MAO
Beta Amyloid
Antibacterial
Potassium Channel
NF-κB
P-gp
Gamma-secretase
Monoamine Oxidase
P2X Receptor
Cannabinoid Receptor
Norepinephrine
Serotonin Transporter
Sodium Channel
Parasite
FAAH
CaMK
Cytochromes P450
Neurokinin receptor
Reactive Oxygen Species
Neuropeptide Y Receptor
BACE
NO Synthase
P2Y Receptor
PDE
TNF
GPCR
Sigma receptor
Antibiotic
OX Receptor
Lipoxygenase
Antioxidant
Influenza Virus
HIV Protease
NOS
PPAR
Beta-Secretase
IL Receptor
Prostaglandin Receptor
Ferroptosis
Antifungal
ERK
ROS
Melatonin Receptor
Phospholipase
Imidazoline Receptor
Virus Protease
Caspase
MT Receptor
Akt
Adenylyl Cyclase
p38 MAPK
Mitophagy
Drug Metabolite
GlyT
EGFR
PGE Synthase
DNA/RNA Synthesis
Bcl-2 Family
STAT
Chloride channel
Carbonic Anhydrase
Transferase
HCV Protease
Estrogen/progestogen Receptor
Dehydrogenase
PKA
Wnt/beta-catenin
AAK1
PKC
Glucocorticoid Receptor
SARS-CoV
Melanocortin Receptor
AMPK
Phosphatase
GSK-3
MRP
HSV
Interleukin
IκB/IKK
CGRP Receptor
ATPase
Histone Methyltransferase
PI3K
Histone Demethylase
Glutathione Peroxidase
Cholecystokinin Receptor
Serine/threonin kinase
ABC Transporter
Monoamine Transporter
MMP
TGF-beta/Smad
TLR
Tyrosinase
Melanin-concentrating Hormone Receptor (MCHR)
Src
Na+/Ca2+ Exchanger
Reductase
NADPH
RAAS
JNK
PARP
Neurotensin Receptor
VEGFR
Immunology/Inflammation related
Topoisomerase
PAFR
CDK
Mitochondrial Metabolism
Antifection
CCR
Epoxide Hydrolase
cAMP
mTOR
Acyltransferase
transporter
GST
HDAC
MEK
Anti-infection
HIF/HIF Prolyl-Hydroxylase
Advanced Glycation End Products
Transaminase
Amino Acids and Derivatives
Others
Arrestin
IFNAR
DYRK
Lipase
Progesterone Receptor
Estrogen Receptor/ERR
HBV
Leukotriene Receptor
ROCK
IAP
UGT
Bcr-Abl
LDL
Glucosidase
JAK
Aurora Kinase
Epigenetic Reader Domain
IGF-1R
DNA
Androgen Receptor
BCRP
GluCls
Nrf2
RSV
ATM/ATR
Hydroxylase
Gap Junction Protein
Platelet aggregation
DNA Methyltransferase
NOD
Microtubule Associated
p53
FOXO3
Proteasome
MicroRNA
Monocarboxylate transporter
ROR
Integrin
c-Met/HGFR
LPL Receptor
Glutaminyl Cyclase
LTR
Neuropeptide W
gp120/CD4
GTPase
N-Acetylglucosaminyltransferase
Antifolate
Cell Cycle Arrest
Cysteine Protease
Nucleoside Antimetabolite/Analog
FXR
LIM Kinase
Aryl Hydrocarbon Receptor
Myosin
Annexin A
FLAP
Adiponectin Receptor
Raf
Glucagon Receptor
Anion Exchanger
HCN Channel
MAGL
Fatty Acid Synthase
PAK
Bombesin Receptor
Stearoyl-CoA Desaturase (SCD)
ACK1
Angiotensin-converting Enzyme (ACE)
Somatostatin
Indoleamine 2,3-Dioxygenase (IDO)
MAPK
Antiviral
HSP
STING
Free radical scavengers
Aminopeptidase
GPCR19
Casein Kinase
Reverse Transcriptase
Retinoid Receptor
CRISPR/Cas9
Adenosine Deaminase
FGFR
NMU2R
FLT
Syk
NADPH-oxidase
HMG-CoA Reductase
Thrombin
Protease-activated Receptor
Lysosomal Autophagy
FAK
ROS Kinase
AhR
CFTR
S1P Receptor
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