普林斯顿生物分子研究中的常规片段库包含29212个化合物。片段化合物仍然有很高的需求,并且在未来的3-5年内将保持如此。创建几个片段化合物库非常容易且快速,例如:通用片段库(分子量≤300,ClogP≤3,HbD≤3,去除不需要的功能团),氟化片段库(用于NMR 筛选),黄金集(应用Ro3和Veber 规则,应用PAINS 和Lilly MedChem 规则)。普林斯顿生物分子研究中的通用片段库包含29212个化合物。
Fragments are still in high demand and would stay for at least 3-5 years. It is quite easy and fast to create few fragments libraries, e.g.: General Fragments (MW ≤ 300, ClogP ≤ 3, HbD ≤ 3, undesired functionalities removed), Fluorinated Fragments (for NMR screening), Golden set (Ro3 & Veber rules, PAINS + Lilly MedChem rules applied). General Fragment Library in the Princeton BioMolecal Research contains 29212 compounds.