Hydrogen bonding, one of the major types of protein-ligand interactions, commonly occurs between polar residues especially those with hydroxyl moieties. Consequently, polyhydroxylated fragments are frequently found in natural and natural-like compounds such as oxopolyene macrolide antibiotics, polyketide-derived natural products, and statins with 1,2- or 1,3-diol subunits. Considering the above-mentioned observations, we have created a conceptually new set of polyhydroxy compounds. The set comprises compounds bearing at least two hydroxyl groups, which are directly attached to sp3 hybridized carbon atoms.