ReFRAME 相关化合物库

ReFRAME Related Library

产品编号: L9230

2018年Jeff Janes 等人通过数据挖掘和文献查询，构建了ReFRAME 化合物库，在美国国家科学院院刊（PNAS）发表了关于ReFRAME 化合物库的应用和实用性；其中大部分已通过I 期临床研究具有临床安全性，ReFRAME 化合物库临床安全的独特性质将显著缩短候选药物进入临床的时间，降低失败风险，可高效应用于早期药物研发阶段的筛选以及先导化合物的发现。作者分享了ReFRAME 化合物库，旨在促进数据共享和药物发现机会。盖茨基金会和清华大学等创办的全球健康药物研发中心(GHDDI）也将ReFRAME 化合物库应用于抗COVID-19药物研发。 TargetMol 整理了ReFRAME 化合物库包含4080 种化合物，是药物再利用和抗COVID-19药物研发的有效工具。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品编号: L9230

规格

1 mg

30 μL x 10 mM (in DMSO)

50 μL x 10 mM (in DMSO)

100 μL x 10 mM (in DMSO)

250 μL x 10 mM (in DMSO)

特别折扣
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技术资料

陶术生物化合物库目录(60.2 MB)

化合物库操作手册(635 KB)

库化合物信息

Excel

SDF

产品描述

产品描述:

4080化合物的独特集合，可用于高通量筛选和高内涵筛选，是药物再利用和抗COVID-19药物研发的有效工具
部分化合物已上市得到FDA、EMA、NMPA等权威部门审批，大部分已通过I期临床研究;
通过结构多样性聚类分析，具有优良的结构多样性，包含2698个聚类簇（相似程度大于70%的为一簇），平均1.2个化合物一个簇；
涵盖多个研究领域：肿瘤、心血管药物、抗炎/免疫、神经系统药物、呼吸系统药物等；
靶点多样，包括5-HT Receptor、Sodium Channel、p38 MAPK、PI3K、MEK等；
详细的说明书，化合物结构、靶点信息、适应症信息、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

我们的化合物库可以灵活定制！了解更多

化合物库咨询

化合物库组成

Others

Autophagy

Apoptosis

Antibacterial

Antibiotic

Endogenous Metabolite

5-HT Receptor

COX

Adrenergic Receptor

Dopamine Receptor

Parasite

AChR

HIV Protease

Antifungal

DNA/RNA Synthesis

Histamine Receptor

Potassium Channel

Calcium Channel

PDE

Sodium Channel

VEGFR

PI3K

GABA Receptor

PPAR

Cytochromes P450

Topoisomerase

Glucocorticoid Receptor

Dehydrogenase

HCV Protease

Estrogen/progestogen Receptor

Prostaglandin Receptor

Influenza Virus

Reactive Oxygen Species

EGFR

Microtubule Associated

FLT

RAAS

SARS-CoV

Adenosine Receptor

NF-κB

CDK

Ferroptosis

JAK

FGFR

PDGFR

Estrogen Receptor/ERR

HDAC

Nucleoside Antimetabolite/Analog

c-Met/HGFR

Mitophagy

mTOR

Src

p38 MAPK

Androgen Receptor

c-Kit

GPCR

MAO

Reverse Transcriptase

iGluR

GluR

HBV

HSV

TRP/TRPV Channel

Opioid Receptor

Virus Protease

Antioxidant

TNF

ATPase

Progesterone Receptor

Proteasome

PKC

ROS

Aurora Kinase

Bcr-Abl

Carbonic Anhydrase

HSP

NMDAR

Akt

MEK

Raf

Tyrosine Kinases

Antiviral

Lipoxygenase

IL Receptor

Serotonin Transporter

AMPK

Antifection

Cholinesterase (ChE)

Endothelin Receptor

MMP

P-gp

ALK

Beta Amyloid

CCR

Integrin

Norepinephrine

Phosphatase

Reductase

Retinoid Receptor

STAT

Transferase

Cannabinoid Receptor

CXCR

DPP-4

Epigenetic Reader Domain

LPL Receptor

Phospholipase

ribosome

TLR

Caspase

c-RET

DNA Alkylator/Crosslinker

E1/E2/E3 Enzyme

HIF/HIF Prolyl-Hydroxylase

Histone Methyltransferase

Monoamine Oxidase

PARP

S1P Receptor

Thrombin

Acyltransferase

Drug Metabolite

Gamma-secretase

Mitochondrial Metabolism

Neurokinin receptor

Proton pump

SGLT

Thyroid hormone receptor(THR)

Bcl-2 Family

Cysteine Protease

DNA Alkylation

ERK

NO Synthase

Nrf2

Syk

TGF-beta/Smad

DHFR

DNA-PK

Hedgehog/Smoothened

HMG-CoA Reductase

Interleukin

PKA

Trk receptor

Tyrosinase

Vasopressin Receptor

Aromatase

CaMK

CFTR

FXR

GSK-3

Guanylate cyclase

Hydroxylase

MRP

p53

PLK

ROCK

Sigma receptor

TAM Receptor

Xanthine Oxidase

Amino Acids and Derivatives

Cholecystokinin Receptor

HER

HIF

IGF-1R

RSV

Wnt/beta-catenin

Antifolate

ATM/ATR

CETP

c-Fms

FAK

Glutathione Peroxidase

IκB/IKK

Leukotriene Receptor

LTR

NADPH

OX Receptor

Ras

Serine Protease

Smo

ADC Cytotoxin

Chk

Chloride channel

FAAH

Factor Xa

Glucokinase

IAP

Indoleamine 2,3-Dioxygenase (IDO)

NOS

Platelet aggregation

ABC Transporter

Beta-Secretase

Casein Kinase

JNK

Ligand for E3 Ligase

LPA Receptor

Mdm2

P2X Receptor

P2Y Receptor

Serine/threonin kinase

Aminopeptidase

Annexin A

Aryl Hydrocarbon Receptor

BACE

CaSR

CSF-1R

DNA gyrase

Glucosidase

IDO

Immunology/Inflammation related

Melatonin Receptor

Monoamine Transporter

MT Receptor

NOD

PAK

PGE Synthase

Rho

ROS Kinase

S6 Kinase

Tie-2

BTK

Acetyl-CoA Carboxylase

Adenosine Deaminase

AhR

Anti-infection

DNA

DNA Methyltransferase

Ephrin Receptor

Fatty Acid Synthase

GHSR

IFNAR

Imidazoline Receptor

Kinesin

Molecular Glues

NOD-like Receptor (NLR)

OAT

PAI-1

PDK

ROR

Sirtuin

UGT

Angiotensin-converting Enzyme (ACE)

Arginase

BCRP

Bradykinin Receptor

Complement System

CRFR

CRM1

Decarboxylase

Epoxide Hydrolase

Gap Junction Protein

GlyT

GNRH Receptor

HCN Channel

Hexokinase

IRE1

Isocitrate Dehydrogenase (IDH)

Monocarboxylate transporter

Myosin

Na+/Ca2+ Exchanger

NAMPT

Oxytocin Receptor

PAFR

Pim

Protease-activated Receptor

STING

transporter

Vitamin

Adenylyl Cyclase

Advanced Glycation End Products

ATP Citrate Lyase

cAMP

CGRP Receptor

c-Myc

CRISPR/Cas9

Discoidin Domain Receptor (DDR)

DprE1

DUB

FLAP

Free radical scavengers

Galectin

Glucagon Receptor

GluCls

Glutaminase

Glutathione reductase

gp120/CD4

GPCR19

Histone Demethylase

KSP

LDL

Ligands for Target Protein for PROTAC

Lipid

Liver X Receptor

MAPK

Melanocortin Receptor

MicroRNA

NADPH-oxidase

Na-K-Cl cotransporter

Neprilysin

Neuropeptide Y Receptor

Phosphorylase

Porcupine

RIP kinase

SGK

Somatostatin

Stearoyl-CoA Desaturase (SCD)

Telomerase

Thrombopoietin Receptor

Wee1

Kras

ACK1

Anion Exchanger

ASK

Cell Cycle Arrest

Cell wall

GPX

GSNOR

Hck

Histone Acetyltransferase

Hydrogenase

IRAK

KLF

Lipase

LRRK2

Lysosomal Autophagy

MALT

Melanin-concentrating Hormone Receptor (MCHR)

Methionine Adenosyltransferase (MAT)

MNK

Mucin

N-Acetylglucosaminyltransferase

NEDD8

Neurotensin Receptor

NPC1L1

p97

PAD

PD-1/PD-L1

PERK

PI4K

PKM

Procollagen C Proteinase

Prolyl Endopeptidase (PREP)

PROTACs

Protease

PYK2

Pyroptosis

RANKL/RANK

RAR/RXR

Survivin

Taste receptor

Thioredoxin

TOPK

VDA

VDAC

YAP

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